Vol. 10, Issue 4, Part A (2024)

Leukemia is the most common hematological malignancy in children, particularly acute lymphoblastic leukemia (ALL), which often requires high doses of methotrexate, increasing the risk of oral mucositis (OM). OM is a painful side effect that negatively affects children’s quality of life and treatment adherence. Effective management is important and includes maintaining good oral hygiene, topical agents and pain relief. Recent advancements, such as cryotherapy, low-level laser therapy (LLLT), and natural substances like honey and olive oil, have shown promise in reducing the occurance and grade of OM. Additionally, growth factors like palifermin are emerging as protective options for mucosal protection. Recently Aloe vera is one of the herbal agents known for its healing properties, has gained attention as a potential therapeutic agent for CIOM. Aloe vera possesses anti-inflammatory, antioxidant, and antimicrobial properties, which may help alleviate symptoms and promote healing of the oral mucosa. This reviews focus on the efficacy of Aloe vera and Recent advancements in managing CIOM in children.