The unique tissue that envelops and maintains the teeth is called periodontium. The alveolar bone proper, cementum, gingiva, and Periodontal Ligament (PDL) are its constituent parts. The gingival line, which covers the coronal portion of the alveolar process and indicates the boundary with the non-keratinized buccal mucosa, extends from the gingiva line, which is the exterior surface of the periodontium.

The most often pigmented intraoral tissue is the connected gingiva, which is followed by papillary gingiva and alveolar mucosa. Gingival hyperpigmentation is regarded as one of the primary cosmetic issues in dentistry.

Mesotherapy is a technique commonly applied to introduce various agents to treat oral pigmentation.

The use of vitamin C, also known as ascorbic acid, is common in dermatology to treat skin depigmentation because it inhibits tyrosine activity, which in turn decreases the production of dopaquinone. Antioxidant and anti-inflammatory qualities of vitamin C improve tissue healing and decrease melanin while also aiding in the manufacture of type 1 collagen.

Oral mesotherapy, or intramucosal vitamin C injections, is a preliminary case series intended to demonstrate the clinical efficacy and patient-reported results of treating gingival melanin hyperpigmentation.

Aim: To assess the effectiveness of mesotherapy, or intramucosal injection, in treating gingival hyperpigmentation in smokers and non-smokers

Methodology: Twenty patients with chronic gingivitis-ten smokers and ten non-smokers-were split into groups 1 and 2, respectively, for this study. Every patient received intramuscular local injection of vitamin C in the maxillary and mandibular front region once a week for three to four visits.

The Gingival Pigmentation Index, developed by Kumar et al. in 2013, will be used to assess the depigmentation.

Result: The present study recorded Gingival Pigmentation Index and taken clinical photographs at baseline and at 3 months, which were significantly improved in smokers compared to non-smokers

Conclusion: Gingival depigmentation can be effectively treated with oral mesotherapy, a minimally invasive, safe, and aesthetically pleasing method that uses locally injected vitamin C.