Vol. 11, Issue 2, Part E (2025)

Background: Regenerative endodontics has emerged as a transformative field in modern dentistry, offering new hope for the treatment of dental pulp and periapical tissues damaged by trauma, infection, or developmental anomalies. This systematic review offers an in-depth exploration of an innovative approach that combines regenerative endodontics with platelet concentrates, a biologically active substance, to enhance the potential for dental tissue regeneration. Regenerative endodontics is focused on reinstating the vitality and functionality of dental tissues, particularly dentin, pulp, and periapical structures, by harnessing the body's natural regenerative capabilities. The process involves thorough sterilization of the root canal system, coupled with the utilization of bioactive agents such as stem cells and growth factors, aimed at stimulating the regeneration of damaged tissues. Platelet concentrates, including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), obtained from the patient's own blood, contain a significant quantity of growth factors crucial for tissue revitalization. The primary objective of this study was to conduct a comprehensive literature review to identify research that adheres to the principles of evidence-based dentistry. The goal was to determine which autologous platelet concentrates are most effective in releasing growth factors for regenerative endodontics, including the recent platelet concentrate known as albumin PRF or alb PRF.
Conclusion: Progress in technological innovations within this field has yielded promising results with respect to the application of platelet concentrates in regenerative endodontic therapy. This systematically reviewed literature concludes that procedures with platelet concentrates play a successful role in treating necrotic or immature teeth. Hence the platelet concentrates can save a tooth by the development of root.