Vol. 11, Issue 3, Part B (2025)

Backround: “The persistence of microorganisms is often regarded as the primary factor contributing to root canal failure. The task of eradicating microorganisms from infected root canal systems is a multifaceted endeavor that requires the utilization of various instrumentation techniques, irrigation protocols, and intracanal medicaments. This comprehensive approach is vital in achieving successful root canal treatment.”

Relying solely on mechanical instrumentation often proves insufficient for achieving a completely bacteria-free root canal system. This is particularly true when taking into account the intricate and complex anatomy of these systems. Additional measures, such as the use of intracanal medicaments and effective irrigation regimens, are typically necessary to achieve the desired level of disinfection. To further reduce the presence of microorganisms, intracanal medicaments are typically used between appointments. While the use of antimicrobial irrigants and medications during canal instrumentation can effectively reduce the bacterial population, it's important to note that some bacteria may still survive in areas such as the lateral and accessory root canals, isthmus, and apical delta.

“The objective of this present study was to carry out a systematic review of the existing literature, with a specific focus on investigations that align with the principles of evidence-based dentistry. The primary objective was to evaluate and ascertain the antibacterial efficacy of different intracanal medicaments against e. faecalis