Vol. 11, Issue 3, Part D (2025)

Introduction: Children's perception of pain is complicated and influenced by a variety of factors, including behavioral, psychological, physiological, and developmental. Pre-emptive analgesia is the practice of giving painkillers before to surgery with the goal of minimizing pain perception both during and after the treatment. The purpose of this systematic review is to evaluate the effectiveness of preventive analgesic medications in children having their primary teeth extracted. The PubMed, Ovid SP and Cochrane databases were searched for potential papers between 1991 and July 2023 by employing pertinent MeSH terms and predetermined inclusion and exclusion criteria that were independently determined by two reviewers. Research that examined the effects of preemptive analgesia medication against placebo for pediatric primary teeth extractions were assessed. The results included the rescue analgesics amount taken overall during the postoperative follow-up period and the patient's self-reported post-operative pain. Preemptive analgesic medication delivery may beneficial during the Deciduous tooth extraction in children, however further research is required to support this theory.