Vol. 11, Issue 4, Part A (2025)

Effective disinfection of the root canal system remains a critical determinant of endodontic success. Conventional irrigation methods often fall short in eliminating biofilms and debris from complex anatomical structures. This has led to the development and integration of various irrigant activation techniques designed to enhance the mechanical and chemical efficacy of root canal debridement. This article provides a comprehensive overview of both traditional and advanced activation methods, including manual dynamic activation, sonic and ultrasonic irrigation, continuous ultrasonic systems, apical negative pressure irrigation, and advanced technologies such as laser-activated irrigation, photoacoustic streaming, SWEEPS, and the multisonic GentleWave system. Each technique’s mechanism of action, clinical protocol, advantages, and limitations are critically discussed. While techniques like Passive Ultrasonic Irrigation and EDDY demonstrate strong performance in smear layer and calcium hydroxide removal, systems like GentleWave and photoacoustic streaming offer promising outcomes in minimally instrumented canals, showing enhanced tissue dissolution and biofilm disruption. Despite technological advancements, no single activation method has proven universally superior across all clinical scenarios. Therefore, selecting an appropriate technique should be based on canal morphology, infection severity, and the desired level of disinfection. Continued research and comparative clinical studies are essential to refine these protocols and optimize patient outcomes. This review emphasizes that combining innovation with sound clinical judgment is key to achieving long-term endodontic success.