Vol. 11, Issue 4, Part B (2025)

Objective: To compare the efficacy of Placental Extract vs. Betamethasone with Hyaluronidase in improving mouth opening among Stage 2 Oral Submucous Fibrosis (OSMF) patients from Arunachal Pradesh.

Study Design: Twenty patients were divided into two equal groups and received biweekly intralesional injections of either Placental extract or Betamethasone with Hyaluronidase for a total of 24 sessions.

Results: Significant increase in mouth opening, evaluated at baseline and after each injection, with statistical analysis showing significant improvement in both groups but no statistically significant difference between them.

Conclusion: Both the Placental extract and Betamethasone with Hyaluronidase are safe and effective options for Stage 2 OSMF management in this population