Vol. 11, Issue 4, Part B (2025)

In oral cancer screening camps, diagnosis relies on visual examination. Exfoliative cytology has proven useful, as cel-lular alterations exhibit distinct histological features even at the early stages. Early detection is crucial for improved outcomes, and chairside adjunct tools can enhance diagnostic accuracy while also serving as educational aids for pa-tients. Foldscope, a low-cost, origami-based portable microscope with 2000× magnification, provides real-time cyto-logical assessment. It serves as an effective tool for bridging diagnostic gaps and enhancing early detection particularly in resource-limited settings. Aims & Objectives of the study is to 1) assess the efficacy of Foldscope as a diagnostic tool for detecting dysplastic changes in exfoliative cytology and 2) to compare its diagnostic accuracy with that of a conventional light microscope in exfoliative cytology. The study population included 30 patients with clinically diag-nosed oral potentially malignant disorders (OPMDs) such as leukoplakia, OSMF, Oral Lichen planus. Oral smears were collected and stained using the Rapid, Economic, Acetic acid Papanicolaou (REAP) stain. Exfoliative cytology smears were then examined under both Foldscope and conventional light microscope, followed by cytomorphometric analy-sis.Comparison of the Nuclear & Cytoplasmic area and N/C ratio between groups revealed no statistically significant differences (p value >0.05) between Conventional Light microscope and Foldscope. These findings suggest that Fold-scope is equally effective in detecting dysplastic changes in exfoliative cytology and can serve reliable, low cost alter-native, especially in resource constrained setting.