Vol. 12, Issue 1, Part B (2026)

Excessive presence of free radicals due to oxidative stress or antioxidant deficiency can result in increased levels of Reactive Oxygen Species (ROS) and reactive nitrogen species (RNS), resulting in various inflammatory pathways leading to periodontal destruction. Antioxidants can be used as adjuncts as they act via signal transduction pathways for the management of periodontitis, however the resources on genetic implication of antioxidants is limited. Nutrigenomics, an emerging branch of science, can be implicated in the study of how dietary antioxidant affects the periodontium on a genetic level. This review aims to highlight the link between dietary antioxidants and periodontitis on a genetic level.