Introduction: The oral cavity is one of the predominant and prevalent sites of development of potential malignancies, since it comes into direct contact with many carcinogens. Despite monitoring the original tumor site following an advanced surgical and non-surgical therapy, the overall mortality rate remains unchanged probably due to the recurrence of the tumor either locally or at a remote site, development of second primary tumors, even when the surgical margins are histopathologically free from tumor corroborates to the concept of field cancerization.
Aim: To determine the histological characteristics of mucosa which appears normal clinically at different sites from the apparent tumor margins in oral squamous cell carcinoma patients.
Materials and Methods: A total of 15 pre diagnosed cases of oral squamous cell carcinoma were included in the study. The cases were clinically evaluated for safe margins using vital staining and the resected RND specimens were eventually evaluated histologically for field cancerization.
Results: The observations in the present study showed that, 6 (40%) out of 15 cases with tumor infiltration into the adjacent margins (vital stain negative areas) at a distance of 1cm from the so called clinically safe surgical margins even after the surgeons employed vital staining for safe margins during pre-operative period. When the margins were statistically evaluated all parameters showed statistically significant differences.
Conclusion: This study probably assess field cancerization of clinically normal appearing mucosa at different sites from the apparent tumor margins in oral squamous cell carcinoma patients.